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Invitrogen™ P4HTM Recombinant Rabbit Monoclonal Antibody (24GB100)
Rabbit Recombinant Monoclonal Antibody
146.00 € - 500.00 €
Specifications
| Antigen | P4HTM |
|---|---|
| Clone | 24GB100 |
| Content And Storage | -20°C |
| Applications | Flow Cytometry, Western Blot, Immunocytochemistry |
| Classification | Recombinant Monoclonal |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
30276053
|
Invitrogen™
MA557145 |
100 μL |
500.00 €
100µL |
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|
30275829
|
Invitrogen™
MA557146 |
20 μL |
146.00 €
20µL |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
Description
P4HTM Recombinant Monoclonal Antibody for Western Blot, ICC/IF, Flow
Prolyl hydroxylase 4 is a prolyl hydroxylase that modifies HIF-alpha. Classic prolyl hydroxylases are found in the endoplasmic reticulum and modify collagen, whereas HIF is an intracellular protein and the prolyl hydroxylase sites do not resemble those modifying collagen. HIF is a transcriptional complex that plays a critical role in oxygen homeostasis. Prolyl hydroxylase is an essential component of the pathway through which cells sense oxygen. In the presence of oxygen, prolyl hydroxylases convert specific prolyl residues in HIF-alpha to hydroxyproline, leading to HIF-alpha destruction. Low oxygen levels, sensed at the cellular level, cause the HIF conversion to be reduced so that HIF is stable and there is increased angiogenesis. Prolyl hydroxylase 4, specifically, catalyzes the posttranslational formation of 4-hydroxyproline in HIF alpha proteins. It may function as a cellular oxygen sensor and, under normoxic conditions, may targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitylation complex.Specifications
| P4HTM | |
| -20°C | |
| Recombinant Monoclonal | |
| Liquid | |
| IgG | |
| Human | |
| P4HTM | |
| 4933406E20Rik; AI853847; BB128974; EGLN4; FLJ20262; HIFPH4; HIF-PH4; HIF-prolyl hydroxylase 4; HPH-4; hypoxia inducible factor prolyl 4 hydroxylase; hypoxia-inducible factor prolyl 4-hydroxylase; hypoxia-inducible factor prolyl hydroxylase 4; P4H TM; P4H with transmembrane domain; P4HTM; P4H-TM; PH 4; PH4; PH-4; PHD4; proline 4-hydroxylase; prolyl 4-hydroxylase, transmembrane; prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum); Prolyl hydroxlase domain-containing 4; RGD1311848; Transmembrane prolyl 4-hydroxylase | |
| P4HTM | |
| Primary | |
| Affinity chromatography |
| 24GB100 | |
| Flow Cytometry, Western Blot, Immunocytochemistry | |
| Unconjugated | |
| Rabbit | |
| RUO | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| Q9NXG6 | |
| 54681 | |
| A synthesized peptide derived from human HIF Prolyl Hydroxylases (aa 70-100). | |
| Antibody |
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