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Invitrogen™ p53R2 Polyclonal Antibody
Goat Polyclonal Antibody
Brand: Invitrogen™ PA5148758
This item is not returnable.
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Description
Reconstitute at 0.2 mg/mL in sterile PBS.
The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 signaling, including p53R2, Chk2, p53AIP1, Noxa, PIDD, and PID/MTA2, were recently discovered. p53R2 is a p53 inducible gene that contains a p53 binding sequence and encodes a subunit of the enzyme ribonucleotide reductase. p53R2 is induced by the reagents, ultraviolet and -gamma-irradiation that cause DNA damages. The product of p53R2 gene is directly involved in the p53 checkpoint for repair of damaged DNA. The isoform of the p53 family member p73 also induces p53R2 expression. p53R2 is an important target of p53 for tumor suppression.
Specifications
| p53R2 | |
| Polyclonal | |
| Unconjugated | |
| Rrm2b | |
| MTDPS8A; MTDPS8B; p53-inducible ribonucleotide reductase small subunit 2 homolog; p53-inducible ribonucleotide reductase small subunit 2 short form beta; p53-inducible ribonucleotide reductase small subunit 2-like protein; p53R2; Ribonucleoside-diphosphate reductase subunit M2 B; ribonucleotide reductase M2 B (TP53 inducible); ribonucleotide reductase regulatory TP53 inducible subunit M2B; RRM2B; TP53-inducible ribonucleotide reductase M2 B | |
| Goat | |
| Antigen affinity chromatography | |
| RUO | |
| 50484 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Lyophilized |
| Western Blot | |
| 0.2 mg/mL | |
| PBS with trehalose and no preservative | |
| Q7LG56 | |
| Rrm2b | |
| E. coli-derived recombinant human p53R2, Met1-Lys180. | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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