missing translation for 'onlineSavingsMsg'
Learn More
Learn More
Invitrogen™ PCK1 Monoclonal Antibody (789114)
Mouse Monoclonal Antibody
Brand: Invitrogen™ MA561800
This item is not returnable.
View return policy
Description
Reconstitute with sterile PBS to a final concentration of 0.5 mg/mL.
Phosphoenolpyruvate Carboxykinase 1 (PCK1) is a main control point for the regulation of gluconeogenesis. During gluconeogenesis PCK1 acts as the rate-limiting enzyme. PCK1 regulates the formation and maintenance of memory CH8(+) T-cells via gluconeogenesis. PCK1 aids in controlling the levels of metabolic intermediates in the citric acid cycle by regulating cataplerosis and anaplerosis. When glucose levels are high, PCK1 catalyzes the cataplerotic conversion of oxaloacetate to phosphoenolpyruvate (PEP). When they are low it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate. When phosphorylated at Ser-90 by AKT1, PCK1 acts as a protein kinase by reducing the binding affinity to oxaloacetate and promotes an atypical serine protein kinase activity using GTP as the donor. This activity regulates lipogenesis by disrupting the interaction between INSIG proteins and SCAP and promoting nuclear translocation of SREBP proteins and transcription of lipogenesis-related genes. An important paralog of this gene is PCK2.
Specifications
| PCK1 | |
| Monoclonal | |
| 0.5 mg/mL | |
| PBS with trehalose and no preservative | |
| P35558 | |
| PCK1 | |
| E. coli-derived recombinant human PCK1, Met1-Ile88. | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG2b |
| Western Blot | |
| 789114 | |
| Unconjugated | |
| PCK1 | |
| AI265463; GTP; HGNC:8724; MGC22652; PCK; Pck1; Pck-1; PE PEPCKC; PEP carboxykinase; PEPCK; PEPCK1; PEPCKC; PEPCK-C; phosphoenolpyruvate carboxykinase (GTP); phosphoenolpyruvate carboxykinase 1; phosphoenolpyruvate carboxykinase 1 (soluble); phosphoenolpyruvate carboxykinase 1, cytosolic; phosphoenolpyruvate carboxykinase, cytosolic; phosphoenolpyruvate carboxykinase, cytosolic (GTP); phosphoenolpyruvate carboxykinase, cytosolic [GTP]; phosphoenolpyruvate carboxylase; phosphopyruvate carboxylase; RATPEPCK | |
| Mouse | |
| Protein A/G | |
| RUO | |
| 5105 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Lyophilized |
Product Content Correction
Your input is important to us. Please complete this form to provide feedback related to the content on this product.
Product Title
Spot an opportunity for improvement?Share a Content Correction