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PD98059, MedChemExpress

Product Code. 16484928
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Product Code. 16484928 Supplier Medchem Express Supplier No. HY12028

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Description

MedChemExpress PD98059 is a potent and selective MEK inhibitor with an IC50 of 5 μM.

PD98059 binds to the inactive form of MEK, thereby preventing the activation of MEK1 (IC50 of 2-7 μM) and MEK2 (IC50 of 50 μM) by upstream kinases. PD98059 is a ERK1/2 signaling inhibitor. PD98059 is a ligand for the aryl hydrocarbon receptor (AHR), and suppresses TCDD binding (IC50 of 4 μM) and AHR transformation (IC50 of 1 μM). PD98059 also inhibits autophagy.

Specifications

Chemical Name or Material PD98059
CAS 167869-21-8
Color Yellow
Purity Grade Notes Research
Molecular Formula C16H13NO3
Quantity 10 mg
Solubility Information DMSO : 33.33 mg/mL (124.70 mM; Need ultrasonic) ∣H2O : < 0.1 mg/mL (insoluble)
SMILES O=C1C=C(OC2=CC=CC=C21)C3=CC=CC(OC)=C3N
Molecular Weight (g/mol) 267.28
Formula Weight 267.28
Percent Purity 98.03%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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