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Phospho-Artemis (Ser516) Polyclonal Antibody, Invitrogen™

Product Code. 15585181
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Quantity:
100 μg
Unit Size:
100µg
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15585181 100 μg 100µg
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Product Code. 15585181 Supplier Invitrogen Supplier No. PA538260

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Description

Rabbit Polyclonal Antibody

Distinct DNA repair pathways minimize the consequences of mutagenic events. Reactive oxygen species (ROS) are highly reactive atoms with an unpaired electron that are conducive to double-strand DNA breaking events. Artemis, named after the Greek goddess for the protection of children, is one of the major proteins contributing to the preservation of double-strand breaks in DNA by cutting away the damaged parts of the DNA, which allows the strands to rejoin. Artemis is a single-strand-specific 5′ to 3′ exonuclease that forms a complex with the 469 kDa DNA-dependent protein kinase (DNA-PKcs). DNA-PKcs phosphorylates Artemis, and Artemis acquires endonucleolytic activity on 5′ and 3′ overhangs and hairpins. These activities are essential for V(D)J recombination and for the 5′ and 3′ overhang processing in nonhomologous DNA end joining.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-Artemis (Ser516)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4
Gene DCLRE1C
Gene Accession No. Q96SD1, Q8K4J0
Gene Alias Protein artemis, DNA cross-link repair 1C protein, Protein A-SCID, SNM1 homolog C, hSNM1C, SNM1-like protein, DCLRE1C, ARTEMIS, ASCID, SCIDA, SNM1C
Gene Symbols DCLRE1C
Host Species Rabbit
Immunogen A synthetic phosphopeptide derived from human Artemis around the phosphorylation site of Ser516 (G-G-SP-Q-S)
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 227525, 64421
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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