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  6. Invitrogen™ Phospho-c-Cbl (Tyr774) Recombinant Rabbit Monoclonal Antibody (CblY774-R4C5), Invitrogen™

Invitrogen™ Phospho-c-Cbl (Tyr774) Recombinant Rabbit Monoclonal Antibody (CblY774-R4C5), Invitrogen™
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Product Code. 17126728 Shop All Thermo Scientific Products
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17126728 200 μL 200µL
17186968 20 μL 20µL
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Product Code. 17126728 Supplier Invitrogen™ Supplier No. MA537136

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Description

Rabbit Recombinant Monoclonal Antibody

Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
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Specifications

Antigen Phospho-c-Cbl (Tyr774)
Applications Flow Cytometry, Western Blot
Classification Recombinant Monoclonal
Clone CblY774-R4C5
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.10% BSA, 50% glycerol and 0.02% sodium azide
Gene Cbl
Gene Accession No. P22681, P22682
Gene Alias 4732447J05Rik; Cas-Br-M (murine) ecotropic retroviral transforming sequence; Casitas B-lineage lymphoma; casitas B-lineage lymphoma proto-oncogene; CBL; Cbl proto-oncogene; Cbl proto-oncogene, E3 ubiquitin protein ligase; CBL2; Cbl-2; CBL-3; CBLC; c-Cbl; E3 ubiquitin-protein ligase CBL; FRA11B; fragile site, folic acid type, rare, fra(11)(q23.3); NSLL; oncogene CBL2; proto-oncogene c-Cbl; RGD1561386; RING finger protein 55; RING-type E3 ubiquitin transferase CBL; RNF55; RNF57; signal transduction protein CBL
Gene Symbols Cbl
Host Species Rabbit
Immunogen A synthetic phospho-peptide corresponding to residues surrounding Tyr774 of human phospho c-Cbl.
Purification Method Protein A/G
Quantity 200 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12402, 867
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG κ
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