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Invitrogen™ Phospho-IRAK1 (Ser376) Polyclonal Antibody
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Product Code. 15544551
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Quantity:
100 μL
Unit Size:
100µL
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15544551 100 μL 100µL
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Product Code. 15544551 Supplier Invitrogen™ Supplier No. PA537611

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Description

Rabbit Polyclonal Antibody

A suggested positive control for IHC is human brain tissue.

IL-1 receptor associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways. It is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. IRAK's association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Alternatively, IRAK1 can phosphorylate TIRAP to promote its ubiquitination and subsequent degradation. IRAK1 also phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus. This results in the transcriptional activiation of type I IFN genes, which drive the cell in an antiviral state.
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Specifications

Antigen Phospho-IRAK1 (Ser376)
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Irak1
Gene Accession No. P51617
Gene Alias AA408924; Il1rak; interleukin 1 receptor associated kinase 1; interleukin-1 receptor-associated kinase 1; interleukin-1 receptor-associated kinase-1; IRAK; Irak1; IRAK-1; IRAK1-S; mPLK; pelle; Pelle homolog; pelle-like protein kinase; Plpk; RGD1563841
Gene Symbols Irak1
Host Species Rabbit
Immunogen Peptide sequence around phosphorylation site of Serine 376(Q-S-S(p)-M-V) derived from Human IRAK1.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3654
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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