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Invitrogen™ Phospho-LIMK1 (Thr508) Polyclonal Antibody
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Product Code. 17789973
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Quantity:
100 μL
Unit Size:
100µL
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17789973 100 μL 100µL
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Product Code. 17789973 Supplier Invitrogen™ Supplier No. PA5118559

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of LIMK1 only when phosphorylated at Threonine 508.

LIMK1 is a serine/threonine kinase involved in regulation of actin cytoskeletal changes via phosphorylation of cofilin. LIMK1 has also been implicated in brain development. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is likely to be a component of an intracellular signaling pathway and may be involved in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome.
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Specifications

Antigen Phospho-LIMK1 (Thr508)
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene LIMK1
Gene Accession No. P53667, P53668, P53669
Gene Alias EC 2.7.11.1; kinase LIMK1; KIZ-1; LIM domain kinase 1; lim kinase 1; LIM motif-containing protein kinase; LIM motif-containing protein kinase 1; LIM-domain containing protein kinase 1; LIM-domain containing, protein kinase; LIM-domain containing, protein kinase 1; Limk; LIMK1; LIMK-1
Gene Symbols LIMK1
Host Species Rabbit
Immunogen A synthesized peptide derived from human LIMK1(Accession P53667), corresponding to amino acid residues around phosphorylated Thr508.
Purification Method Sequential Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16885, 3984, 65172
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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