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Invitrogen™ Phospho-MKP1/MKP2 (Ser296, Ser318) Polyclonal Antibody
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Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5104854

Product Code. 16644365

  • 458.00 € / 100µL

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Description

Description

Antibody detects endogenous levels of MKP1/2 only when phosphorylated at Serine 296/318.

There are ten mitogen-activated protein kinase (MAPK) phosphatases (MKPs) that act as negative regulators of MAPK activity in mammalian cells. MKP2 (DUSP4) is a dual threonine/tyrosine phosphatase that specifically dephosphorylates and inactivates MAPKs (ERK, JNK, p38). It contains one Rhodanese domain and one tyrosine-protein phosphatase domain. MKP2 is expressed in a variety of tissues, and is localized in the nucleus. Transcription factor E2F-1 acts as a transcriptional regulator of MKP2. E2F-1/MKP2 pathway mediates apoptosis under oxidative stress and that MKP2 suppresses tumor formation. MKP2 is a novel transcription target of p53 in mediating apoptosis by 10-bp palindrome motif (CTGGCGCCAG) in the MKP2 promoter.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Phospho-MKP1/MKP2 (Ser296, Ser318)
Polyclonal
Unconjugated
DUSP1
2700078F24Rik; 3CH134; 3CH134/CL100 PTPase; AI844617; BB104621; CL 100; CL100; dual specificity phosphatase 1; dual specificity phosphatase 4; dual specificity protein phosphatase 1; Dual specificity protein phosphatase 4; dual specificity protein phosphatase hVH1; Dual specificity protein phosphatase hVH2; DUSP 4; DUSP1; Dusp4; DUSP-4; E130306H24Rik; erp; HVH1; HVH2; MAP kinase phosphatase 1; MAP kinase phosphatase 2; MAP kinase phosphatase-1; mitogen-activated protein (MAP) kinase phosphatase-1; mitogen-activated protein kinase phosphatase 1; Mitogen-activated protein kinase phosphatase 2; mitogen-activated protein kinase phosphatase-1; MKP II; Mkp1; mkp-1; Mkp2; Mkp-2; MKPII; oxidative stress-inducible protein tyrosine phosphatase; protein tyrosine phosphatase non-receptor type 16; protein tyrosine phosphatase, non-receptor type 16; protein-tyrosine phosphatase 3CH134; Protein-tyrosine phosphatase CL100; protein-tyrosine phosphatase ERP; Protein-tyrosine phosphatase non-receptor type 16; PTPN10; Ptpn16; serine/threonine specific protein phosphatase; TYP; U19515; VH1; VH1 homologous phosphatase 2; VH2
Rabbit
Sequential Chromatography
RUO
114856, 1843, 1846, 19252, 319520, 60587
-20°C
Liquid
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
P28562, P28563, Q13115, Q62767, Q64623, Q8BFV3
DUSP1, DUSP4
A synthesized peptide derived from human DUSP1(Accession P28562), corresponding to amino acid residues around phosphorylated Ser296.
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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