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Phospho-MKP1/MKP2 (Ser296, Ser318) Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA539795

Product Code. 15576661

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Description

Description

There are ten mitogen-activated protein kinase (MAPK) phosphatases (MKPs) that act as negative regulators of MAPK activity in mammalian cells. MKP2 (DUSP4) is a dual threonine/tyrosine phosphatase that specifically dephosphorylates and inactivates MAPKs (ERK, JNK, p38). It contains one Rhodanese domain and one tyrosine-protein phosphatase domain. MKP2 is expressed in a variety of tissues, and is localized in the nucleus. Transcription factor E2F-1 acts as a transcriptional regulator of MKP2. E2F-1/MKP2 pathway mediates apoptosis under oxidative stress and that MKP2 suppresses tumor formation. MKP2 is a novel transcription target of p53 in mediating apoptosis by 10-bp palindrome motif (CTGGCGCCAG) in the MKP2 promoter.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Phospho-MKP1/MKP2 (Ser296, Ser318)
Polyclonal
Unconjugated
DUSP4
Mitogen-activated protein kinase phosphatase 2, MAP kinase phosphatase 2, MKP-2, Dual specificity protein phosphatase hVH2, DUSP-4, DUSP 4, MKPII, MKP II, Dual specificity protein phosphatase 1, MAP kinase phosphatase-1, MKP-1, Protein-tyrosine phosphatase CL100, Dual specificity protein phosphatase hVH1, CL100, MKP1, PTPN10, VH1
Rabbit
Antigen affinity chromatography
RUO
114856, 1843, 1846, 19252, 319520, 60587
-20°C
Liquid
Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4
P28562, Q13115, P28563, Q8BFV3, Q62767, Q64623
DUSP1, DUSP4
A synthetic phosphopeptide derived from human MKP-1/2 around the phosphorylation site of Ser296/318 (I-I-SP-P-N)
100 μg
Primary
Human, Mouse, Rat
Antibody
IgG
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