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Phospho-PERK (Thr980) Monoclonal Antibody (G.305.4), Invitrogen™
Rabbit Monoclonal Antibody
Brand: Invitrogen MA515033
Code : LE
Additional Details : Weight : 0.01000kg
Description
It is not recommended to aliquot this antibody.
EIF2AK3 (PERK) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein sythesis. In the case of EIF2AK3, signaling is initiated by misfolded proteins in the ER. Defects in EIF2AK3 are the cause of Wolcott-Rallison syndrome (WRS), also known as multiple epiphyseal dysplasia with early-onset diabetes mellitus. WRS is a rare autosomal recessive disorder, characterized by permanent neonatal or early infancy insulin-dependent diabetes and, at a later age, epiphyseal dysplasia, osteoporosis, growth retardation and other multisystem manifestations, such as hepatic and renal dysfunctions, mental retardation and cardiovascular abnormalities.Specifications
| Phospho-PERK (Thr980) | |
| Monoclonal | |
| 441 μg/mL | |
| 0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and <0.02% sodium azide; pH 7.5 | |
| Q9Z1Z1 | |
| EIF2AK3 | |
| Synthetic phosphopeptide corresponding to residues surrounding pThr980 of mouse PERK | |
| 100 μL | |
| Primary | |
| Rat | |
| Antibody | |
| IgG |
| Western Blot | |
| G.305.4 | |
| Unconjugated | |
| EIF2AK3 | |
| 2.7.11.1; AI427929; EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3; eukaryotic translation initiation factor 2-alpha kinase 3; HsPEK; OTTHUMP00000207187; OTTHUMP00000207188; Pancreatic eIF2-alpha kinase; PEK; Perk; PRKR-like endoplasmic reticulum kinase; WRS | |
| Rabbit | |
| Affinity chromatography | |
| RUO | |
| 29702 | |
| -20°C | |
| Liquid |