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Description
Glycosylated PON1 migrates at 42-45 kDa. 55 kDa is a dimmer of isoform CRA-b. The antibody has cross-reaction to PON2 and PON3.
The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3.
Specifications
Specifications
| Antigen | PON1 |
| Applications | Immunoprecipitation, Western Blot, Immunohistochemistry (Paraffin) |
| Classification | Polyclonal |
| Concentration | 0.15 mg/mL |
| Conjugate | Unconjugated |
| Formulation | PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 |
| Gene | PON1 |
| Gene Accession No. | P27169, P52430, P55159, Q15165, Q15166, Q62086, Q62087, Q68FP2, Q6AXM8 |
| Gene Alias | A esterase 1, Aromatic esterase 1, ESA, K 45, paraoxonase 1, PON, PON 1, PON1, Serum aryldialkylphosphatase 1 |
| Gene Symbols | Pon1, Pon2, PON3 |
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