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  6. Invitrogen™ RAP80 Recombinant Rabbit Monoclonal Antibody (K01_2P24)

Invitrogen™ RAP80 Recombinant Rabbit Monoclonal Antibody (K01_2P24)
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Product Code. 30830063
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30830063 100 μL
30830387 50 μL
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Product Code. 30830063 Supplier Invitrogen™ Supplier No. MA564188

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Description

Rabbit Recombinant Monoclonal Antibody

RAP80 Recombinant Monoclonal Antibody for ICC/IF, IHC (P), Western Blot

RAP80 was initially identified as zinc-finger containing nuclear protein that is highly expressed in testis and interacts with the retinoid-related testis-associated receptor (RTR). Later experiments revealed that RAP80 is recruited by the Coiled-coil domain 98 (CCDC98) protein to the breast cancer-1 protein BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both RAP80 and CCDC98 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either RAP80 or CCDC98 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that RAP80 and CCDC98 control only part of the DNA damage response role of BRCA1. At least four isoforms of RAP80 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RAP80
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone K01_2P24
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 50mM tris glycine with 150mM NaCl, 40% glycerol, 0.05% BSA and 0.01% sodium azide; pH 7.4
Gene UIMC1
Gene Accession No. Q96RL1
Gene Alias 9430016E08Rik; BRCA1-A complex subunit RAP80; D330018D10Rik; D630032M02Rik; RAP80; Receptor-associated protein 80; retinoid X receptor interacting protein 110; retinoid X receptor-interacting protein 110; RGD1307009; RIP110; Rxrip110; ubiquitin interaction motif containing 1; ubiquitin interaction motif-containing protein 1; Uimc1; X2HRIP110
Gene Symbols UIMC1
Host Species Rabbit
Immunogen A synthetic peptide of human RAP80.
Purification Method Protein A/G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 51720
Target Species Human
Content And Storage Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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