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  6. RU.521, MedChemExpress

RU.521, MedChemExpress

Product Code. 16487537
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Product Code. 16487537

Brand: Medchem Express HY114180

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Description

MedChemExpress RU.521 (RU320521) is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor and inhibits cGAS-mediated interferon upregulation. RU.521 suppresses dsDNA-activated reporter activity with an IC50 of 0.7 μM. RU.521 reduces constitutive expression of interferon in macrophages from a mouse model of Aicardi-Goutières syndrome (AGS).

RU.521 (RU320521) is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor and inhibits cGAS-mediated interferon upregulation. RU.521 suppresses dsDNA-activated reporter activity with an IC50 of 0.7 μM. RU.521 reduces constitutive expression of interferon in macrophages from a mouse model of Aicardi-Goutières syndrome (AGS).

Specifications

Chemical Name or Material RU.521
Physical Form Solid
CAS 2262452-06-0
Color White
Quantity 5 mg
Purity Grade Notes Research
Molecular Formula C19H12Cl2N4O3
For Use With (Application) Metabolism-protein/nucleotide metabolism
Synonym RU320521
Solubility Information DMSO : 83.33 mg/mL (200.68 mM; Need ultrasonic)
SMILES O=C1OC(C2=C(O)N(C3=NC4=CC=C(Cl)C(Cl)=C4N3)N=C2C)C5=C1C=CC=C5
Molecular Weight (g/mol) 415.23
Formula Weight 415.23
Percent Purity 98.67%
Grade Research
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Research purposes only

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