Invitrogen™ RYK Monoclonal Antibody (F35 P7 D7 F5)

Description

This antibody detects RYK in human, mouse, and rat samples. MA1-615 has been successfully used in Western blot, procedures. By Western blot this antibody detects the RYK receptor-like tyrosine kinase-1 in cells. The MA1-615 immunogen corresponds to the ovalbumin-conjugated synthetic peptide C (462) L T E F H A A L G A Y V(475).

RYK is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. A nine nucleotide insertion in some transcripts results in the SLG variant. It is not established whether this is a product of alternative splicing or a second gene, since evidence for a second gene or pseudogene on chromosome 17 exists.