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  6. Invitrogen™ Sall1 Monoclonal Antibody (NRNSTNX), Alexa Fluor™ 647, eBioscience™, Invitrogen™

Invitrogen™ Sall1 Monoclonal Antibody (NRNSTNX), Alexa Fluor™ 647, eBioscience™, Invitrogen™

Product Code. 17158645
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100 μg
25 μg
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25µg
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Product Code. 17158645 Supplier Invitrogen™ Supplier No. 51972980

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Description

Rat Monoclonal Antibody

Description: This NRNSTNX monoclonal antibody recognizes mouse Sall1. Applications Reported: This NRNSTNX antibody has been reported for use in intracellular staining followed by flow cytometric analysis. Applications Tested: This NRNSTNX antibody has been tested by intracellular staining followed by flow cytometric analysis of mouse brain cells using the Intracellular Fixation & Permeabilization Buffer Set (Product # 88-8824-00) and protocol. Please refer to Staining Intracellular Antigens for Flow Cytometry, Protocol A: Two step protocol for intracellular (cytoplasmic) proteins located at www.thermofisher.com/flowprotocols. This may be used at less than or equal to 0.5 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Excitation: 633-647 nm; Emission: 668 nm; Laser: Red Laser

Sall1, which encodes a zinc finger protein, functions as a transcriptional repressor and interacts physically with histone deacetylase and other components of the chromatin remodeling NuRD complex. It is unknown whether the transcriptional repression is solely dependent on histone deacetylase activity. Gene expression profiling has identified Sall1 as a microglial signature gene. Microglia are the resident macrophages of the central nervous system (CNS). Sall1 is also expressed in abundance in the mesenchyme-derived structure from condensed mesenchyme, S-comma-shaped bodies, to renal tubules and podocytes. Sall1 has been identified as a key transcription factor in self-renewal renal progenitor cells. Sall1 is required to maintain the stemness of nephron progenitor cells by restraining their differentiation into renal vesicles. Defects in SALL1 are the cause of Townes-Brocks syndrome as well as bronchio-oto-renal syndrome. Heterozygous mutations of human SALL1 leading to Townes-Brocks syndrome features dysplastic ears, preaxial polydactyly, imperforate anus, and less commonly, kidney and heart anomalies (Kohlhase et al. 1998). Two transcript variants encoding different isoforms have been found for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Sall1
Applications Flow Cytometry
Classification Monoclonal
Clone NRNSTNX
Concentration 0.2 mg/mL
Conjugate Alexa Fluor 647
Formulation PBS with 0.09% sodium azide; pH 7.2
Gene SALL1
Gene Accession No. Q9ER74
Gene Alias epididymis secretory protein Li 89; HEL-S-89; HSal1; Msal-3; SAL1; Sal-1; sal-3; SALL1; sal-like 1; sal-like 1 (Drosophila); sal-like protein 1; spalt like transcription factor 1; spalt-like transcription factor 1; TBS; Zinc finger protein 794; zinc finger protein SALL1; Zinc finger protein Spalt-1; zinc finger protein Spalt-3; ZNF794
Gene Symbols SALL1
Host Species Rat
Immunogen C-terminal fragment of the protein (aa-805-1322).
Purification Method Affinity chromatography
Quantity 25 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 58198
Target Species Mouse
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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