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Invitrogen™ SIT Polyclonal Antibody
Goat Polyclonal Antibody
Brand: Invitrogen™ PA5148945
This item is not returnable.
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Description
Reconstitute at 0.2 mg/mL in sterile PBS.
SIT (SHP2-interacting transmembrane adaptor protein) is expressed exclusively in lymphoid organs and acts either as a positive or as a negative regulatory element in T cell activation and in T cell development. Binding to Grb2 plays a pivotal role in signal transduction. Hubener et al. (2001) determined that the SIT gene contains 5 exons and spans 1.8 kb of genomic DNA. The SIT promoter demonstrated strong transcriptional activity and potential binding sites for both ubiquitous and lymphoid-specific transcription factors.
Specifications
| SIT | |
| Polyclonal | |
| Unconjugated | |
| SIT1 | |
| gp30/40; MGC125908; MGC125909; MGC125910; RP11-331F9.5; SHP2 interacting transmembrane adaptor; SHP-2 interacting transmembrane adaptor protein; SHP2-interacting transmembrane adapter protein; SHP2-interacting transmembrane adaptor protein; signaling threshold regulating transmembrane adaptor 1; signaling threshold-regulating transmembrane adapter 1; SIT; SIT1; SIT-R; suppression inducing transmembrane adaptor 1; suppression-inducing transmembrane adapter 1 | |
| Goat | |
| Antigen affinity chromatography | |
| RUO | |
| 27240 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Lyophilized |
| Western Blot | |
| 0.2 mg/mL | |
| PBS with trehalose and no preservative | |
| Q9Y3P8 | |
| SIT1 | |
| E. coli-derived recombinant human SIT1, Gln65-Ser196. | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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