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Invitrogen™ STAC2 Polyclonal Antibody
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Product Code. 16688354
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Quantity:
100 μL
Unit Size:
100µL
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16688354 100 μL 100µL
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Product Code. 16688354 Supplier Invitrogen™ Supplier No. PA5101884

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total STAC2.

STAC2 (SH3 and cysteine-rich domain-containing protein 2), also known as 24b2/STAC2, is a 411 amino acid protein that contains one SH3 domain and one phorbol-ester/DAG-type zinc finger. Encoding two alternatively spliced isoforms, the STAC2 gene contains over 15 thousand bases and maps to human chromosome 17q12. Human chromosome 17 comprises over 2.5% of the human genome and encodes over 1, 200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.
TRUSTED_SUSTAINABILITY

Specifications

Antigen STAC2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene STAC2
Gene Accession No. Q6ZMT1, Q8R1B0
Gene Alias 24b2; 24b2/STAC2; AW240854; SH3 and cysteine rich domain 2; SH3 and cysteine-rich domain-containing protein 2; Src homology 3 and cysteine-rich domain-containing protein 2; Stac2
Gene Symbols STAC2
Host Species Rabbit
Immunogen A synthesized peptide derived from human STAC2(Accession Q6ZMT1), corresponding to amino acid residues A215-P265.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 217154, 342667, 363674
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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