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T Cell Receptor Gamma/Delta Hamster, anti-Mouse, FITC, Clone: GL3, STEMCELL Technologies
Hamster Monoclonal Antibody
Brand: Stemcell Technologies 60104FI
Additional Details : Weight : 0.00110kg
Description
- The GL3 antibody reacts with the δ chain of the murine T cell receptor γ/δ (TCRγ/δ or TCR gamma/delta), a subtype of the TCR involved in the recognition of both peptide and lipid antigens
- TCRγ/δ comprises a heterodimer (∼ 80 kDa in humans) of disulfide-linked γ and δ subunits that associates with CD3 on the cell surface
- It is a member of the immunoglobulin superfamily
- TCRγ/δ is expressed on a subpopulation of T cells in the circulation but may be found on up to 50% of the T cells in epithelial cell-rich tissues
- These cells have roles in oral and tumor-associated tolerance as well as autoimmune disease and have been described as a link between the adaptive and innate immune responses
- Once activated, they secrete effector cytokines in a subtype- and context-specific manner
- Most γ/δ T cells are CD4-/CD8-, though some express CD8
- The GL3 antibody recognizes an epitope in the constant region of the δ chain and can reportedly activate TCRγ/δ+ cells
Specifications
| T Cell Receptor Gamma/Delta | |
| Monoclonal | |
| FITC | |
| 200 μg | |
| Mouse | |
| T Cells, T Cells, Other Subsets |
| Immunohistochemistry, Flow Cytometry, Immunofluorescence, Functional Assay, Blocking Assay | |
| GL3 | |
| Hamster | |
| Primary | |
| IgG2 κ |