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Tamoxifen, MP Biomedicals

Product Code. 15712262 Shop All MP Biomedicals Products
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Quantity:
1 g
5 g
Unit Size:
1g
5g
Product Code. Quantity unitSize
15712262 5 g 5g
11455161 1 g 1g
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Product Code. 15712262

Brand: MP Biomedicals 0215673894

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Description

Tamoxifen, White Powder

  • It has been used to facilitate the recombination of ect2flox allele in mouse organs.
  • It has also been used to study its effect on lipopolysaccharide (LPS)-induced microglial activation.
  • Protein kinase C inhibitor (IC50 = 50-200μM depending on assay conditions in MCF-7 cells or IC50 = 100μM in rat brain).
  • It is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 10540-29-1
Molecular Formula C26H29NO
Molecular Weight (g/mol) 371.52
MDL Number MFCD00010454
InChI Key NKANXQFJJICGDU-QPLCGJKRSA-N
SMILES CC\C(=C(/C1=CC=CC=C1)C1=CC=C(OCCN(C)C)C=C1)C1=CC=CC=C1

Specifications

Melting Point 96°C to 100°C
Color White
Loss on Drying 0.0021
Refractive Index KR5919600
Quantity 5 g
Synonym [Z]-1-[p-Dimethylaminoethoxyphenyl]-1,2-diphenyl-1-butene, (Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine, ICI 47699, trans-Tamoxifen
Solubility Information Practically insoluble in water (< 0.01% at 20°C); soluble in methanol, ethanol, 2-propanol, propyleneglycol, chloroform (50mg/mL - clear, colorless to faint yellow solution) or DMSO
IUPAC Name (2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}ethyl)dimethylamine
Physical Form Powder
Assay 0.9935

Safety and Handling

compliance-icons compliance-icons
Product Identifier
  • Tamoxifen, Free Base
 Signal Word
  • Danger
 Hazard Category
  • Carcinogenicity Category 1A
  • Reproductive toxicity Category 1A
 Hazard Statement
  • H350-May cause cancer.
  • H360-May damage fertility or the unborn child.
 Precautionary Statement
  • P101-If medical advice is needed, have product container or label at hand.
  • P102-Keep out of reach of children.
  • P103-Read label before use.
  • P263-Avoid contact during pregnancy/while nursing.
  • P308+P313-IF exposed or concerned: Get medical advice/attention.
  • P405-Store locked up.
  • P501b-Dispose of contents/container in accordance with local/regional/national/international regulations.
 Supplemental information
  • MIXTURE LIST-Contains : tamoxifen free base
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