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Invitrogen™ TIGIT Chimeric Recombinant Rabbit Monoclonal Antibody (1B4)
Rabbit Recombinant Monoclonal Antibody
Brand: Invitrogen™ MA548199
This item is not returnable.
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Description
Specificity: This antibody is specific for murine TIGIT.
TIGIT is a 26 kDa protein that belongs to the poliovirus receptor (PVR) family. It is expressed on NK cells, regulatory T cells, follicular T helper cells, memory CD4+ T cells, and CD8+ T cells, but not on B cells or naive CD4+ T cells. However, TIGIT can be upregulated on naive CD4+ T cells upon activation. TIGIT interacts with members of the PVR and PVR-like families, including CD155. This interaction mediates the engagement of NK and T cells with antigen-presenting cells, fibroblasts, and endothelial cells expressing PVR and PVR-like proteins. Binding of TIGIT to PVR leads to increased secretion of IL-10 and decreased secretion of IL-12B, promoting the generation of mature immunoregulatory dendritic cells and suppressing T cell activation. Through these interactions, TIGIT plays a significant role in modulating immune responses and maintaining immune homeostasis.
Specifications
| TIGIT Chimeric | |
| Recombinant Monoclonal | |
| 1 mg/mL | |
| PBS with 0.02% ProClin 300 | |
| P86176 | |
| TIGIT | |
| This antibody was raised by immunising TIGIT-/- mice with recombinant murine TIGIT tetramers. | |
| 200 μg | |
| Primary | |
| Mouse | |
| Antibody | |
| IgG λ |
| ELISA, Flow Cytometry, Inhibition Assays, Western Blot | |
| 1B4 | |
| Unconjugated | |
| TIGIT | |
| ENSMUSG00000071552; T cell immunoreceptor with Ig and ITIM domains; T-cell immunoreceptor with Ig and ITIM domains; TIGIT; V-set and immunoglobulin domain containing 9; V-set and immunoglobulin domain-containing protein 9; V-set and transmembrane domain containing 3; V-set and transmembrane domain-containing protein 3; VSIG9; VSTM3; Washington University cell adhesion molecule; WUCAM | |
| Rabbit | |
| Protein A | |
| RUO | |
| 100043314 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
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