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Description
Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predomit TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. Probably necessary for normal neurologic development.
Specifications
Specifications
| Antigen | TIMM8A |
| Applications | Immunofluorescence, Immunocytochemistry, Immunoprecipitation, Western Blot |
| Classification | Polyclonal |
| Concentration | 0.6 mg/mL |
| Conjugate | Unconjugated |
| Formulation | PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 |
| Gene | TIMM8A |
| Gene Accession No. | O60220, Q9WVA2 |
| Gene Alias | DDP, DDP1, Deafness dystonia protein 1, DFN1, MTS, TIM8, TIM8A, TIMM8A |
| Gene Symbols | TIMM8A, Timm8a1 |
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Product Title
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