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Invitrogen™ TOLLIP Polyclonal Antibody
Sheep Polyclonal Antibody
Brand: Invitrogen™ PA5148882
This item is not returnable.
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Description
Reconstitute at 0.2 mg/mL in sterile PBS.
Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules to activate various kinases and transcription factors so the organism can respond to potential infection. These adaptor molecules include TOLLIP, MyD88, and TRIF. TOLLIP associates directly with TLR2 and TLR 4, acting as an inhibitor to TLR activation. This negative regulation of TLR signaling may serve to limit the production of proinflammatory mediators during infection and inflammation.
Specifications
| TOLLIP | |
| Polyclonal | |
| Unconjugated | |
| TOLLIP | |
| 4930403G24Rik; 4931428G15Rik; adapter protein; EMBL:AAI33068.1}; FLJ33531; IL-1RAcPIP; toll interacting protein; toll-interacting protein; TOLLIP; tollip {ECO:0000312 | |
| Sheep | |
| Antigen affinity chromatography | |
| RUO | |
| 54472 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Lyophilized |
| Western Blot | |
| 0.2 mg/mL | |
| PBS with trehalose and no preservative | |
| Q9H0E2 | |
| TOLLIP | |
| E. coli-derived recombinant human Tollip, Met1-Pro274. | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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