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Invitrogen™ TRAF5 Polyclonal Antibody
Sheep Polyclonal Antibody
Brand: Invitrogen™ PA5148693
This item is not returnable.
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Description
Reconstitute at 0.2 mg/mL in sterile PBS.
Tumor necrosis factor (TNF) induced signaling is mediated through association of TNF receptor (TNFR) with adaptor proteins, such as TNF receptor associated proteins (TRAFs). TRAFs form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily (e. g. RANK, CD30, CD40, etc. ) and the interleukin-1 receptor. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. Recent molecular cloning studies have lead to identification of six TRAFs (TRAF1-TRAF6) (1-4). TRAF5 is a 558-amino acid protein. TRAF5 is implicated in NF-kB and c-Jun NH(2)-terminal kinase/stress-activated protein kinase activation by members of the TNF receptor superfamily, including CD27, CD30, CD40, and lymphotoxin-beta receptor. Targeted disruption of TRAF5 gene causes defects in CD40-CD27 mediated lymphocyte activation (5).
Specifications
| TRAF5 | |
| Polyclonal | |
| Unconjugated | |
| TRAF5 | |
| 2700049M22Rik; AI875481; AU022477; BH3 interacting domain death agonist; BH3-interacting domain death agonist; BH3-interacting domain death agonist p11; BH3-interacting domain death agonist p13; BH3-interacting domain death agonist p15; BID; MGC:39780; p11 BID; p13 BID; p15 BID; p22 BID; RING finger protein 84; RNF84; TNF receptor associated factor 5; TNF receptor-associated factor 5; Traf5 | |
| Sheep | |
| Antigen affinity chromatography | |
| RUO | |
| 7188 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Lyophilized |
| Immunohistochemistry (Paraffin) | |
| 0.2 mg/mL | |
| PBS with trehalose and no preservative | |
| O00463 | |
| TRAF5 | |
| E. coli-derived recombinant human TRAF-5, Lys353-Leu557. | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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