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Invitrogen™ TSPO Monoclonal Antibody (CL13358)
GREENER_CHOICE

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA546545

Product Code. 17809165

  • 433.00 € / 100µL

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Description

Description

Highest antigen sequence indentity to the following orthologs: Rat - 75%, Mouse - 81%.

Mitochondrial peripheral-type benzodiazepine receptor (PBR) is an indispensable element of the steroidogenic machinery, where it mediates the delivery of cholesterol to the inner mitochondrial side chain cleavage cytochrome P-450 upon ligand activation. PBR is composed of three subunits, an isoquinoline binding site, a voltage-dependent anion channel and an adenine nucleotide carrier. PBR is genetically conserved from bacteria to humans and in humans is widely expressed in peripheral organs, whereas in the brain, it is sparse and located mainly in glial cells. Peroxisome proliferator perfluordecanoic acid (PFDA) inhibits the Leydig cell steroidogenesis by affecting PBR mRNA stability, thus inhibiting PBR expression, cholesterol transport into the mitochondria and subsequent steroid formation. A cytoplasmic protein, PRAX-1 ( peripheral benzodiazepine receptor-associated protein 1), is found to specifically interact with PBR.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

TSPO
Monoclonal
0.97 mg/mL
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
P30536
Tspo
Synthetic Peptide.
100 μL
Primary
Human
Antibody
IgG2b
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
CL13358
Unconjugated
Tspo
Benzodiazepin receptor (peripheral); benzodiazepine peripheral binding site; benzodiazepine receptor, peripheral; BPBS; BZRP; DBI; IBP; isoquinoline-binding protein; MBR; mDRC; mitochondrial benzodiazepine receptor; OTTHUMP00000028891; PBR; PBS; peripheral-type benzodiazepine receptor; pk18; PKBS; PTBR; Ptbzr; PTBZR02; RATPTBZR02; translocator protein; translocator protein (18kDa); TSPO; Tspo1
Mouse
Protein A
RUO
706
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
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