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Invitrogen™ Ub-K63 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA5120617
This item is not returnable.
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Description
Positive test controls include: HeLa, HeLa+MG132, NIH/3T3, C6, Mouse brain, Rat brain.
Ubiquitin is a conserved 76 amino acid polypeptide and can affect proteasomal degradation of the protein it is bound to, or mediate interactions with other proteins related to post-translational modifications. The degradation of cellular regulatory proteins by the Uubiquitin pathway is important as it controls the cellular growth and proliferation. Ubiquitin-dependent proteolysis occurs after a covalent attachment of the peptide to a lysine residue of a protein, which involves three enzymatic reactions: E1, E2 and E3. The first reaction involves ubiquitin-activating enzyme. The third reaction uses enzyme ubiquitin ligase (E3) to transfer the activated ubiquitin from E2 to a lysine residue on a protein, or directly transfers the ubiquitin from E2 to the substrate.
Specifications
| Ub-K63 | |
| Polyclonal | |
| Unconjugated | |
| UBB | |
| 0610006J14Rik; 2700054O04Rik; 40S ribosomal protein S27a; 60S ribosomal protein L40; AI194771; AL033289; CEP52; CEP80; D8Ertd21e; epididymis luminal protein 112; epididymis secretory protein Li 50; Gm1863; HEL112; HEL-S-50; HMG20; HUBCEP52; L40; Large ribosomal subunit protein eL40; LOC100912032; polyubiquitin B; polyubiquitin C; polyubiquitin-B; Polyubiquitin-C; ribosomal protein S27A; RPL40; Rps27a; S27A; Small ribosomal subunit protein eS31; TI-225; Uba52; UBA80; Ubb; Ubb2; UBC; UBCEP1; UBCEP2; UBCEP80; Ubiquitin; Ubiquitin A-52 residue ribosomal protein fusion product 1; ubiquitin and ribosomal protein S27a; ubiquitin B; ubiquitin C; ubiquitin carboxyl extension protein 52; ubiquitin carboxyl extension protein 80; ubiquitin/60S ribosomal fusion protein; Ubiquitin-40S ribosomal protein S27a; ubiquitin-40S ribosomal protein S27a-like; ubiquitin-52 amino acid fusion protein; ubiquitin-60S ribosomal protein L40; ubiquitin-CEP52; ubiquitin-CEP80; Ubiquitin-related; Ubiquitin-related 1; Ubiquitin-related 2 | |
| Rabbit | |
| Affinity Chromatography | |
| RUO | |
| 100912032, 192255, 22186, 22187, 22190, 50522, 6233, 64156, 7311, 7314, 7316, 78294 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Liquid |
| Dot Blot, ELISA | |
| 0.29 mg/mL | |
| PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3 | |
| P0CG47, P0CG48, P0CG49, P0CG50, P0CG51, P62979, P62982, P62983, P62984, P62986, P62987, Q63429 | |
| RPS27A, UBA52, UBB, UBC | |
| A synthetic peptide corresponding to a sequence containing polyubiquitinated protein (K63 linkage). | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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