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Invitrogen™ Cathepsin A Monoclonal Antibody (179803)
Mouse Monoclonal Antibody
Brand: Invitrogen™ MA560888
This item is not returnable.
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Description
Reconstitute at 0.5 mg/mL in sterile PBS.
The cathepsin family of proteolytic enzymes include several diverse classes of proteases. Cathepsins B, L, H, K, S and O comprise the cysteine protease class. Cathepsins D and E comprise the aspartyle protease class. The serine protease class includes cathepsin G. Cathepsins function in cellular metabolism and participate in peptide biosynthesis and protein degradation. Cathepsin A, a serine carboxypeptidase, exists in a high molecular weight lysosomal complex with b-galactosidase (b-gal) and a-neuraminidase (Neu1). Cathepsin A functions to protect b-gal and Neu1 from intralysosomal proteolysis. Deficiencies in cathepsin A lead to deficiencies in b-gal and Neu1. The gene encoding human cathepsin A maps to chromosome 20q13.12. Mutations in this gene cause glactosialidosis, a lysosomal storage disorder resulting from the b-gal and Neu1 deficiencies.
Specifications
| Cathepsin A | |
| Monoclonal | |
| 0.5 mg/mL | |
| PBS with trehalose and no preservative | |
| P10619 | |
| CTSA | |
| Mouse myeloma cell line NS0-derived recombinant human Cathepsin A/Lysosomal Carboxypeptidase A, Ala29-Tyr480 (predicted). | |
| 500 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG2a |
| Immunoprecipitation, Western Blot | |
| 179803 | |
| Unconjugated | |
| CTSA | |
| AU019505; beta-galactosidase 2; beta-galactosidase protective protein; carboxypeptidase C; Carboxypeptidase L; carboxypeptidase Y-like kininase; carboxypeptidase-L; cathepsin A; CTSA; deamidase; GLB2; GSL; lysosomal carboxypeptidase A; lysosomal protective protein; Lysosomal protective protein 20 kDa chain; Lysosomal protective protein 32 kDa chain; NGBE; PPCA; PPGB; protective protein cathepsin A; Protective protein for beta-galactosidase; urinary kininase | |
| Mouse | |
| Protein A/G | |
| RUO | |
| 5476 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Lyophilized |
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