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LPIN3 Mouse anti-Human, Clone: OTI1B10, lyophilized, TrueMAB™

Product Code. 17678261
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Quantity:
100 μg
Unit Size:
100µg
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17678261 100 μg 100µg
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Product Code. 17678261 Supplier Origene Technologies Supplier No. CF805037

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Description

Mouse Monoclonal Antibody

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Humans lipodystrophy is characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance. Mice carrying mutations in the fatty liver dystrophy gene have similar phenotypes. Through positional cloning, the mouse gene responsible for fatty liver dystrophy was isolated and designated Lpin1. The nuclear protein encoded by Lpin1 was named lipin. Lpin1 mRNA was expressed at high levels in adipose tissue and was induced during differentiation of preadipocytes. These results indicated that lipin is required for normal adipose tissue development and provided a candidate gene for human lipodystrophy. Through database searches, mouse and human EST and genomic sequences with similarities to Lpin1 were identified. These included two related mouse genes and three human homologs. Human LPIN1 gene has been mapped to 2p25.; linkages of fat mass and serum leptin levels to this same region have been noted. Human LPIN2 and LPIN3 mapped to chromosomes 18p11 and 20q11-q12, respectively. The mouse genes encoding Lpin1, Lpin2, and Lpin3 mapped to chromosome 12, 17, and 2, respectively.

Specifications

Antigen LPIN3
Applications Western Blot
Classification Monoclonal
Clone OTI1B10
Conjugate Unconjugated
Formulation PBS with 8% trehalose and no preservative; pH 7.3
Gene LPIN3
Gene Accession No. Q9BQK8
Gene Alias LIPN3L, SMP2
Gene Symbols LPIN3
Host Species Mouse
Immunogen Full length human recombit protein of human LPIN3 produced in HEK293T cell.
Purification Method Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 64900
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG2b
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