Small interfering RNA/silencing RNA (siRNA) is a class of double-stranded, non-coding RNA molecule, 20-25 base pairs in length. As part of the RNA interference pathway, it regulates gene expression by degrading mRNA after transcription, preventing translation.
Silencer™ Select siRNAs are the result of recent improvements in siRNA design combined with novel chemical modifications yielding unrivaled knockdown efficiency and specificity. Our best performing siRNA for cell culture work. Silencer™ siRNAs are unmodified 21 nucleotide siRNAs that have been designed with an older, yet rigorously tested design algorithm. A lower cost alternative to Silencer™ Select siRNAs, but without some of the performance enhancements.
Contains dried siRNA and Nuclease-free Water (1.75 mL), shipped at ambient temperature. Upon receipt, store siRNAs in a non-frost-free freezer at or below –20 °C
Silencer™ Select siRNAs are classic 21-mers which incorporate the latest improvements in siRNA design, off-target effect prediction algorithms, and chemistry.
Silencer™ Select siRNAs are classic 21-mers which incorporate the latest improvements in siRNA design, off-target effect prediction algorithms, and chemistry.
The Silencer™ Select Human Long Noncoding RNA (lncRNA) siRNA Library contains 15,081 Ambion™ Silencer Select siRNAs targeting 5,027 lncRNAs as identified in GENCODE v22.
Mutations that cause a loss or reduction in gene function can result in the progression to cancer, usually in combination with other genetic changes. Tumor suppressor genes, or anti-oncogenes, can protect cells on the path to becoming cancerous.