CAS RN 142273-20-9
CAS RN 142273-20-9
IUPAC Name:
14-bromo-8,18-diazatetracyclo[9.7.0.0²,⁷.0¹²,¹⁷]octadeca-1(11),2,4,6,12,14,16-heptaen-9-one
Synonyms:
14-bromo-8,18-diazatetracyclo[9.7.0.0²,⁷.0¹²,¹⁷]octadeca-1(11),2,4,6,12,14,16-heptaen-9-one
Molecular Weight (g/mol):
327.18
Molecular Formula:
C16H11BrN2O
InChi Key:
QQUXFYAWXPMDOE-UHFFFAOYSA-N
SMILES:
BrC1=CC=C2NC3=C(CC(=O)NC4=CC=CC=C34)C2=C1
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Kenpaullone, MedChemExpress
MedChemExpress Kenpaullone is a potent inhibitor of CDK1/cyclin B and GSK-3β, with IC50s of 0.4 μM and 23 nM, and also inhibits CDK2/cyclin A, CDK2/cyclin E, and CDK5/p25 with IC50s of 0.68 μM, 7.5 μM, 0.85 μM, respectively. Kenpaullone, a small molecule inhibitor of KLF4, reduces self-renewal of breast cancer stem cells and cell motility in vitro.
