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Btk Mouse anti-Human, Unlabeled, Clone: 53/BTK, BD
Mouse Monoclonal Antibody
172.83 € - 357.38 €
Specifications
| Antigen | Btk |
|---|---|
| Clone | 53/BTK |
| Concentration | 250μg/mL |
| Applications | Western Blot |
| Classification | Monoclonal |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
15895799
|
BD Biosciences
611116 |
50 μg |
 180.00 € 172.83 € / 1 set Save 7.17 € 3% Off |
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|
15805809
|
BD Biosciences
611117 |
150 μg |
372.00 € 357.38 € / 1 set Save 14.62 € 3% Off |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
Description
Bruton's tyrosine kinase (Btk) is a nonreceptor tyrosine kinase whose function is critical for proper B cell development and signaling. It is a member of the Tec family of kinases which includes Tec and Itk. In addition to an N-terminal pleckstrin homology (PH) domain, the Tec proteins contain Src homology domains 2 and 3 (SH2 and SH3) and a stretch of 60-80 amino acids between the PH and SH3 domains termed the Tec homology domain. The activity of Btk is regulated by Src-mediated phosphorylation of the kinase domain at tyrosine 551. This event induces Btk kinase activity and subsequent autophosphorylation at tyrosine 223 in the SH3 domain. Phosphorylated Btk then associates with the cell membrane via the interaction of the PH domain with phosphatidylinositol 3, 4, 5-triphosphate. The PH domain is essential for proper activation and function of Btk. A mutation in the PH domain results in Xid, murine X-linked immunodeficiency, and human X-linked agammaglobulinemia.
Host Species: Mouse
Clone: 53
Isotype: IgG2a
Species Reactivity: Human
Immunogen: Human N-Terminal Btk aa. 2-172 Recombinant Protein
Formula Weight [Chemical]: 77kDa
Immunofluorescence, Western Blotting
Specifications
| Btk | |
| 250μg/mL | |
| Monoclonal | |
| Mouse | |
| Cell Biology | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| IgG2a | |
| Affinity Purified |
| 53/BTK | |
| Western Blot | |
| Unconjugated | |
| RUO | |
| Human | |
| Human N-Terminal Btk aa. 2-172 Recombinant Protein | |
| Primary | |
| Store undiluted at -20°C. |
For Research Use Only.
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