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Lymphotoxin-alpha/TNF-beta, Mouse anti-Human, Clone: 3F12.2D3, Novus Biologicals™
Mouse Monoclonal Antibody
250.00 € - 665.00 €
Specifications
| Antigen | Lymphotoxin-alpha/TNF-beta |
|---|---|
| Clone | 3F12.2D3 |
| Concentration | 1 mg/mL |
| Dilution | Flow Cytometry, ELISA, Surface Plasmon Resonance, Neutralization |
| Applications | Flow Cytometry, ELISA, Neutralization |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
18315750
|
Novus Biologicals
NBP2-81106-0.025MG |
0.025 mg |
250.00 €
25µg |
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|
18302441
|
Novus Biologicals
NBP2-81106-0.2MG |
0.2 mg |
665.00 €
0.20mg |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
Description
Lymphotoxin-alpha/TNF-beta Monoclonal specifically detects Lymphotoxin-alpha/TNF-beta in Human samples. It is validated for Flow Cytometry, ELISA, Surface Plasmon Resonance, Neutralization.Specifications
| Lymphotoxin-alpha/TNF-beta | |
| 1 mg/mL | |
| Flow Cytometry, ELISA, Neutralization | |
| Unconjugated | |
| Mouse | |
| Adaptive Immunity, Apoptosis, Asthma, Biologically Active Proteins, Cytokine Research, Immunology, Innate Immunity | |
| PBS | |
| 4049 | |
| 3F12 was prepared by hyperimmunizing BALB/c mice with purified recombinant human LTalpha expressed in E. coli - the hybridoma clone was selected for its ability to bind LTalpha3 by ELISA. The CDRs of the antibody were grafted to the framework regions of the mice mAb 2G7 to create the chimeric version of the antibody. | |
| Primary | |
| Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
| 3F12.2D3 | |
| Flow Cytometry, ELISA, Surface Plasmon Resonance, Neutralization | |
| Monoclonal | |
| Purified | |
| RUO | |
| Human | |
| LT, LT-alpha, lymphotoxin alpha (TNF superfamily, member 1), TNFBlymphotoxin-alpha, TNFSF1TNF-beta, tumor necrosis factor beta, Tumor necrosis factor ligand superfamily member 1 | |
| LTA | |
| IgG2b κ | |
| Protein A purified | |
| 3F12 binds to human LTalpha3 and LT-alpha-beta (with a KD of ∽0.3 nM, determined by BIACORE; ∽ 37 pM, determined by ELISA) in both its soluble homotrimeric and membrane heterotrimeric forms. LTalpha belongs to the tumor necrosis factor (TNF) superfamily and is secreted as a homo-trimer (LTalpha3), or is expressed on the cell surface in complex with LTbeta. Lymphotoxin is produced by lymphocytes and in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. LTalpha3 signaling induces target cells to upregulate many chemokines and cytokines in an NFkB-dependent manner. |
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