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Invitrogen™ MBD1 Recombinant Rabbit Monoclonal Antibody (24GB405)
Rabbit Recombinant Monoclonal Antibody
Brand: Invitrogen™ MA557470
This item is not returnable.
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Description
MBD1 Recombinant Monoclonal Antibody for Western Blot, Flow
Methyl-CpG-binding domain protein 1 (MBD1) is a member of a family of mammalian proteins that specifically bind methylated regions of DNA. It is a transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). MBD1 acts as a transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.
Specifications
| MBD1 | |
| Recombinant Monoclonal | |
| Unconjugated | |
| MBD1 | |
| CXXC3; CXXC-type zinc finger protein 3; Mbd1; methyl-CpG binding domain protein 1; methyl-CpG binding domain protein 1 isoform PCM1; methyl-CpG-binding domain protein 1; Methyl-CpG-binding protein MBD1; PCM1; Protein containing methyl-CpG-binding domain 1; RFT; the regulator of fibroblast growth factor 2 (FGF-2) transcription | |
| Rabbit | |
| Affinity chromatography | |
| RUO | |
| 291439, 4152 | |
| -20°C | |
| Liquid |
| Flow Cytometry, Western Blot, Immunocytochemistry | |
| 24GB405 | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| Q9UIS9 | |
| MBD1 | |
| A synthesized peptide derived from human MBD1 (aa 550-605). | |
| 100 μL | |
| Primary | |
| Human, Rat | |
| Antibody | |
| IgG |
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