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Invitrogen™ TIGIT Monoclonal Antibody (MBSA43), NovaFluor™ Red 700, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
Brand: Invitrogen™ H011T02R03-A
This item is not returnable.
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Description
TIGIT is a 26 kDa protein that belongs to the poliovirus receptor (PVR) family. It is expressed on NK cells, regulatory T cells, follicular T helper cells, memory CD4+ T cells, and CD8+ T cells, but not on B cells or naive CD4+ T cells. However, TIGIT can be upregulated on naive CD4+ T cells upon activation. TIGIT interacts with members of the PVR and PVR-like families, including CD155. This interaction mediates the engagement of NK and T cells with antigen-presenting cells, fibroblasts, and endothelial cells expressing PVR and PVR-like proteins. Binding of TIGIT to PVR leads to increased secretion of IL-10 and decreased secretion of IL-12B, promoting the generation of mature immunoregulatory dendritic cells and suppressing T cell activation. Through these interactions, TIGIT plays a significant role in modulating immune responses and maintaining immune homeostasis.
Specifications
| TIGIT | |
| Monoclonal | |
| 0.8 μg/Test | |
| PBS with 0.09% sodium azide; pH 7.2 | |
| Q495A1 | |
| TIGIT | |
| Affinity chromatography | |
| RUO | |
| 201633 | |
| 4°C, store in dark, DO NOT FREEZE! | |
| Liquid | |
| IgG1 κ |
| Flow Cytometry | |
| MBSA43 | |
| NovaFluor Red 700 | |
| TIGIT | |
| ENSMUSG00000071552; T cell immunoreceptor with Ig and ITIM domains; T-cell immunoreceptor with Ig and ITIM domains; TIGIT; V-set and immunoglobulin domain containing 9; V-set and immunoglobulin domain-containing protein 9; V-set and transmembrane domain containing 3; V-set and transmembrane domain-containing protein 3; VSIG9; VSTM3; Washington University cell adhesion molecule; WUCAM | |
| Mouse | |
| 25 Tests | |
| Primary | |
| Human | |
| Antibody | |
| Liquid |
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